President Atta Mills came to power in 2009
Ghana's President John Atta Mills, who was suffering from throat cancer, has died in hospital in the capital, Accra.
A statement from his office said the 68-year-old died a few hours after being taken ill, but did not give details.
"It is with a heavy heart... that we announce the sudden and untimely death of the president of the Republic of Ghana," the statement said.
Mr Atta Mills had ruled the West African country since 2009.
The BBC's Sammy Darko, who is at the military hospital in Accra, says Mr Atta Mills' voice has been degenerating in the last few months.
'Rumours'
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For the past three or four years there's been news he's been unwell and rumours of his death - twice - and he appeared with grim humour to say they were exaggerated, insisting he was well”
Elizabeth OheneJournalist
According to a presidential aide, the leader had complained of pains on Monday evening and died on Tuesday afternoon, Reuters reports.
He had recently returned to Ghana after visiting the US for medical checks, the news agency says.
Vice-President John Dramani Mahama will be sworn in as president at 1800 GMT, in line with Ghana's constitution.
Journalist Elizabeth Ohene, a former BBC editor and member of Ghana's former government, said she had not believed the news at first, as there had been many false reports about his death.
"For the past three or four years there's been news he's been unwell and rumours of his death - twice - and he appeared with grim humour to say they were exaggerated, insisting he was well," she told the BBC's Focus on Africa programme.
Mr Atta Mills came to power after narrowly winning against a candidate from the then governing New Patriotic Party, Nana Akufo-Addo, in polls in December 2008.
His predecessor, John Kufuor, had to step down after having served the maximum permitted two four-year terms.
It was Mr Mills' third attempt to
win the presidency, after defeat in 2000 and 2004 to Mr Kufuor.
He was to run for a second term in December.
(New York Timez) In shocking news for the whole of Africa,
Meles Zenawi has passed away from acute justifribilasis fatilosis* at
the age of 57. No other leader in the history of the third world has done more
to lift his country from the clutches of poverty and delivered Ethiopia into the
forefront of modernity in less than 22 years of rule than has the cherished
leader of Ethiopia Meles Zenawi. His Excellency Zenawi leaves behind a country
that is flourishing and his legacy will forever be etched in all Africans as an
intellectual giant who has done more for Africa than Nelson Mandela could have
done in five lifetimes. Today is a sad day for all Africans as a son of
Ethiopia has been called home by his maker.
